Many transcription factors contribute toC. elegansgrowth and fat storage

Shared transcription factors contribute to distinct cell fates

Genome-wide transcription factor (TF) binding profiles differ dramatically between cell types. However, not much is known about the relationship between cell-type-specific binding patterns and gene expression. A recent study demonstrated how the same TFs can have functional roles when binding to largely non-overlapping genomic regions in hematopoietic progenitor and mast cells. Cell-type specif...

Adipocyte Fatty Acid Storage Factors Enhance Subcutaneous Fat Storage in Postmenopausal Women

Increases in weight have been associated with corresponding increases in insulin resistance in postmenopausal women. Although estrogen has significant impact on body fat and body fat distribution, the cellular mechanisms that influence this process are not yet known. We measured adipose tissue fatty acid (FA) storage and FA storage factors in 12 premenopausal and 11 postmenopausal women matched...

Defective fat storage

Like baby chicks, stem cells need a nest—a niche within the body where they reside and self-renew. Oguro et al. (page < A r t R e f v o l = " 2 0 3 " I s s = " 1 0 " > 2247< / A r t R e f >) find that, for blood stem cells, this nest is built by the same gene silencer that also helps them self-renew. This silencer is Bmi1, which turns off two cell cycle inhibitor genes, Ink4a and Arf, to promot...

Front Matters and ToC

HOW MANY FACTORS ? 1 Question Number Two : How Many Factors ?

Exploratory factor analysis involves five key decisions. The second decision, how many factors to retain, is the focus of the current paper. Extracting too many or too few factors often leads to devastating effects on study results. The advantages and disadvantages of the most effective and/or most utilized strategies to determine the number of factors to extract will be explored. Equipped with...